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Vistide and Renal dysfunction

Result of checking the interaction of drug Vistide and disease Renal dysfunction for safety when used together.

Check result:

Vistide <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The initiation of cidofovir therapy is contraindicated in patients with renal impairment defined by a serum creatinine > 1.5 mg/dL, a calculated creatinine clearance <= 55 mL/min, or a urine protein >= 100 mg/dL (i.e., 2+ proteinuria). Cidofovir is associated with dose-dependent nephrotoxicity, which may result in acute renal failure and the need for dialysis in some cases, as well as Fanconi's syndrome. Patients with normal renal function or mild dysfunction should be monitored closely for declining renal function during cidofovir therapy, and the dosing adjusted or discontinued accordingly. Renal function should be assessed within 48 hours preceding each dose.

References:

Lalezari JP, Drew WL, Glutzer E, James C, Miner D, Flaherty J, Fisher PE, Cundy K, Hannigan J, Martin JC, et al "(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue." J Infect Dis 171 (1995): 788-96
"Product Information. Vistide (cidofovir)." Gilead Sciences, Foster City, CA.
Polis MA, Spooner KM, Baird BF, Manischewitz JF, Jaffe HS, Fisher PE, Falloon J, Davey RT Jr, Kovacs JA, Walker RE, et al "Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria." Antimicrob Agents Chemother 39 (1995): 882-6

Vistide

Generic Name: cidofovir

Brand Name: Vistide

Synonyms: n.a.

What is Vistide?