Drug search by name

Wytensin and Liver disease

Result of checking the interaction of drug Wytensin and disease Liver disease for safety when used together.

Check result:

Wytensin <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Guanabenz is primarily metabolized by the liver. Pharmacokinetic data indicate that the plasma clearance of guanabenz is significantly reduced and its elimination half-life significantly prolonged in patients with liver disease. Therapy with guanabenz should be administered cautiously in patients with impaired hepatic function. Careful monitoring of blood pressure during dosage titration is recommended.

References:

"Product Information. Wytensin (guanabenz)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Lasseter KC, Shapse D, Pascucci VL, Chiang ST "Pharmacokinetics of guanabenz in patients with impaired liver function." J Cardiovasc Pharmacol 6 (1984): s766-70

Wytensin

Generic Name: guanabenz

Brand Name:

Synonyms: Wytensin (Oral)

What is Wytensin?