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Xalkori and Hepatic impairment

Result of checking the interaction of drug Xalkori and disease Hepatic impairment for safety when used together.

Check result:

Xalkori <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Crizotinib is extensively metabolized in the liver, and hepatic impairment is likely to increase plasma crizotinib concentrations. Cases of drug-induced hepatotoxicity with fatal outcomes have been reported with the use of crizotinib. It is recommended to monitor liver function tests, regularly as clinically indicated, with more frequent repeat testing for increased liver transaminases, alkaline phosphatase, or total bilirubin in patients who develop transaminase elevations and to temporarily suspend, reduce the dose, or permanently discontinue therapy as per recommended by the manufacturer. Caution is recommended in patients with hepatic impairment.

Xalkori

Generic Name: crizotinib

Brand Name: Xalkori

Synonyms: n.a.

What is Xalkori?