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Etrafon Forte and Seizure disorders

Result of checking the interaction of drug Etrafon Forte and disease Seizure disorders for safety when used together.

Check result:

Etrafon Forte <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tricyclic antidepressants (TCAs), can lower the seizure threshold and trigger seizures. These drugs should be used with extreme caution in patients with a history of seizures, or other predisposing factors, such as head trauma, CNS abnormalities, and alcoholism. Daily dose restrictions might apply for specific antidepressants. Physicians are encouraged to get additional dosing recommendations on the manufacturer's prescribing information.

References:

Pascual J, Combarros O, Berciano J "Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment." Clin Neuropharmacol 10 (1987): 565-7
"Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.
Robinson ML "Epileptic fit after clomipramine." Br J Psychiatry 132 (1978): 525-6
Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30
Flechter S, Rabey JM, Regev I, Borenstein N, Vardi J "Convulsive attacks due to antidepressant drug overdoses: case reports and discussion." Gen Hosp Psychiatry 5 (1983): 217-21

Etrafon Forte

Generic Name: amitriptyline / perphenazine

Brand Name: Etrafon Forte, Triavil, Etrafon 2-10, Etrafon 2-25

Synonyms: n.a.

What is Etrafon Forte?

Another drug Delete

Etrafon Forte <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Phenothiazines can lower the seizure threshold and induce seizures, particularly when dosages are high or increased rapidly and during the initiation of therapy. Of the phenothiazines used in the treatment of psychosis, chlorpromazine appears to have the greatest epileptogenic potential, while fluphenazine and thioridazine have the least. Therapy with phenothiazines should be administered cautiously in patients with a history of seizures or other factors predisposing to seizures such as abnormal EEG, preexisting CNS pathology, or head trauma. Adequate anticonvulsant therapy should be maintained during administration of phenothiazines.

References:

DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
"Product Information. Tacaryl (methdilazine)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Vesprin (triflupromazine)" Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Mellaril (thioridazine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
"Product Information. Stelazine (trifluoperazine)" SmithKline Beecham, Philadelphia, PA.
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Sparine (promazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Prolixin (fluphenazine)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
"Product Information. Compazine (prochlorperazine)." SmithKline Beecham, Philadelphia, PA.
Markowitz J, Brown R "Seizures with neuroleptics and antidepressants." Gen Hosp Psychiatry 9 (1987): 135-41
"Product Information. Trilafon (perphenazine)" Schering Corporation, Kenilworth, NJ.
"Product Information. Temaril (trimeprazine)" Allergan Inc, Irvine, CA.
Waterhouse RG "Epileptiform convulsions in children following premedication with Pamergan SP100." Br J Anaesth 39 (1967): 268-70
"Product Information. Thorazine (chlorpromazine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.