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Betamethasone sodium phosphate and betamethasone acetate Injection and Myasthenia gravis

Result of checking the interaction of drug Betamethasone sodium phosphate and betamethasone acetate Injection and disease Myasthenia gravis for safety when used together.

Check result:

Betamethasone sodium phosphate and betamethasone acetate Injection <> Myasthenia gravis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Although corticosteroids are commonly used in the treatment of myasthenia gravis to increase muscle strength, these agents should nevertheless be administered with caution in such setting. Patients should be treated in an intensive care unit and receive respiratory support, since muscle strength may markedly decrease initially, particularly with high dosages. Preferably, therapy should begin with relatively low dosages (15 to 25 mg/day of prednisone or equivalent) and be increased stepwise as tolerated (approximately 5 mg/day of prednisone or equivalent at 2- to 3-day intervals until marked clinical improvement or a dosage of 50 mg/day is reached). Improvement may be delayed and gradual. Thus, it is important not to discontinue therapy prematurely.

References:

Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):

Betamethasone sodium phosphate and betamethasone acetate Injection

Generic Name: betamethasone

Brand Name: Celestone Soluspan, Celestone, Celestone Phosphate, Selestoject, Cell-U-Jec, Adbeon, Beta-Phos/AC

Synonyms: Betamethasone (injection), Betamethasone (Systemic)

What is Betamethasone sodium phosphate and betamethasone acetate Injection?