Drug search by name

Blenoxane and Renal dysfunction

Result of checking the interaction of drug Blenoxane and disease Renal dysfunction for safety when used together.

Check result:

Blenoxane <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Bleomycin is primarily eliminated by the kidney. Approximately 60% to 70% of bleomycin is excreted in the urine as active drug. Moderate renal failure reduces elimination to < 20% of the drug. Extreme caution should be exercised when administering bleomycin in patients with existing or predisposition to significantly compromised renal function. Close clinical monitoring of renal function is recommended.

References:

"Product Information. Blenoxane (bleomycin)." Bristol-Myers Squibb, Princeton, NJ.
Bennett WM, Pastore L, Houghton DC "Fatal pulmonary bleomycin toxicity in cisplatin-induced acute renal failure." Cancer Treat Rep 64 (1980): 921-4
McLeod BF, Lawrence HJ, Smith DW, Vogt PJ, Gandara DR "Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency." Cancer 60 (1987): 2617-20

Blenoxane

Generic Name: bleomycin

Brand Name: Bleo 15k, Blenoxane

Synonyms: Blenoxane (Injection)

What is Blenoxane?