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Carmustine Intracranial Implant and Pulmonary infiltrates/fibrosis

Result of checking the interaction of drug Carmustine Intracranial Implant and disease Pulmonary infiltrates/fibrosis for safety when used together.

Check result:

Carmustine Intracranial Implant <> Pulmonary infiltrates/fibrosis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pulmonary toxicity characterized by pulmonary infiltrates and/or fibrosis has been reported during carmustine therapy. Toxicity has occurred within nine days of initiation of therapy at doses usually > 1400 mg/m2. However, cases of delayed onset pulmonary fibrosis occurring up to 17 years after treatment have also been reported. Late reduction in pulmonary function, progressive fibrosis, and death have been noted. Risk factors include past history of lung disease and duration of treatment. Therapy with carmustine should be administered cautiously in patients with a history of pulmonary disease. Pulmonary function studies prior to and during therapy are recommended.

References:

Lena H, Desrues B, Le Coz A, Quinquenel ML, Delaval P "Severe diffuse interstitial pneumonitis induced by carmustine (BCNU)." Chest 105 (1994): 1602-3
Weinstein AS, Diener-West M, Nelson DF, Pakuris E "Pulmonary toxicity of carmustine in patients treated for malignant glioma." Cancer Treat Rep 70 (1986): 943-6
Sweet DL "Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)." Ann Intern Med 91 (1979): 132-3
Patten GA, Billi JE, Rotman HH "Rapidly progressive, fatal pulmonary fibrosis induced by carmustine." JAMA 244 (1980): 687-8
Weiss RB, Muggia FM "Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)." Ann Intern Med 91 (1979): 131-2
"Product Information. BiCNU (carmustine)." Bristol-Myers Squibb, Princeton, NJ.
O'Driscoll BR, Kalra S, Gattamaneni HR, Woodcock AA "Late carmustine lung fibrosis. Age at treatment may influence severity and survival." Chest 107 (1995): 1355-7

Carmustine Intracranial Implant

Generic Name: carmustine

Brand Name: BiCNU, Gliadel

Synonyms: Carmustine

What is Carmustine Intracranial Implant?