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Casodex and Hepatic dysfunction

Generic Name: bicalutamide
Dosage Forms: tablet
Other Brand Names: Casodex

Result of checking the interaction of drug Casodex and disease Hepatic dysfunction for safety when used together.

Check result:

Casodex <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Bicalutamide is extensively metabolized by the liver and its metabolism may be altered and/or delayed in patients with moderate to severe hepatic impairment. Therapy with bicalutamide should be administered cautiously in patients with moderate to severe hepatic impairment. Additionally there have been postmarketing reports of death or hospitalization due to severe liver injury (hepatic failure) in association with bicalutamide, so extra caution is advised in patients with hepatic impairment. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Clinical monitoring of hepatic function is recommended. Although hepatic abnormalities such as elevated liver transaminase levels and jaundice are usually reversible, bicalutamide therapy should be discontinued if transaminase levels exceed two times the upper normal limits.

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