Drug search by name

Cefobid injection and Renal/liver disease

Result of checking the interaction of drug Cefobid injection and disease Renal/liver disease for safety when used together.

Check result:

Cefobid injection <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cefoperazone is primarily eliminated by hepatobiliary excretion. In patients with impaired hepatic function and/or biliary obstruction, the half-life of cefoperazone is prolonged 2- to 4-fold but urinary excretion is increased. At usual dosages, adjustments are generally not necessary in either renal or hepatobiliary impairment. However, serum drug concentrations should be monitored if high dosages are used (i.e. > 4 g/day), and the dosage decreased accordingly if drug accumulation occurs. In patients with both hepatic and severe renal impairment, cefoperazone dosage should not exceed 1 to 2 grams per day without close monitoring of serum concentrations.

References:

Greenfield RA, Gerber AU, Craig WA "Pharmacokinetics of cefoperazone in patients with normal and impaired hepataic and renal function." Rev Infect Dis 5 (1983): s127-36
Balant L, Dayer P, Rudhardt M, et al "Cefoperazone: pharmacokinetics in humans with normal and impaired renal function and pharmacokinetics in rats." Clin Ther 3 (1980): 50-9
Saudek F, Moravek J, Modr Z "Cefoperazone pharmacokinetics in patients with liver cirrhosis: a predictive value of the ujoviridin test." Int J Clin Pharmacol Ther Toxicol 27 (1989): 82-7
"Product Information. Cefobid (cefoperazone)." Roerig Division, New York, NY.
Muder RR, Agarwala S, Mirani A, Gayowski T, Venkataramanan R "Pharmacokinetics of cefoperazone and sulbactam in liver transplant patients." J Clin Pharmacol 42 (2002): 644-50
Boscia JA, Korzeniowski OM, Snepar R, et al "Cefoperazone pharmacokinetics in normal subjects and patients with cirrhosis." Antimicrob Agents Chemother 23 (1983): 385-9
Neu HC "A review and summary of the pharmacokinetics of cefoperazone: a new, extended-spectrum B-lactam antibiotic." Ther Drug Monit 3 (1981): 121-8
Bolton WK, Scheld WM, Spyker DA, Sande MA "Pharmacokinetics of cefoperazone in normal volunteers and subjects with renal insufficiency." Antimicrob Agents Chemother 19 (1981): 821-5
Cochet B, Belaieff J, Allaz AF, et al "Serum levels and urinary excretion of cefoperazone in patients with hepatic insufficiency." Infection 9 (1981): s37-9

Cefobid injection

Generic Name: cefoperazone

Brand Name:

Synonyms: Cefobid

What is Cefobid injection?