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Cefotetan Injection and Disulfiram-like reaction

Result of checking the interaction of drug Cefotetan Injection and disease Disulfiram-like reaction for safety when used together.

Check result:

Cefotetan Injection <> Disulfiram-like reaction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Disulfiram-like reactions may occur in patients who consume alcohol within 72 hours after administration of a cephalosporin antibiotic that contains an N-methylthiotetrazole (NMTT) side chain (cefamandole, cefmetazole, cefoperazone, cefotetan). The reaction appears to result from accumulation of acetaldehyde due to inhibition of acetaldehyde dehydrogenase. Therapy with cephalosporins containing the NMTT side chain should be administered cautiously in patients with a history of alcoholism. Patients should be instructed to avoid alcohol-containing products during therapy and up to 72 hours after the last dose.

References:

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"Product Information. Cefobid (cefoperazone)." Roerig Division, New York, NY.
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"Product Information. Zefazone (cefmetazole)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals, Wilmington, DE.
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Freundt KJ, Schreiner E, Christmann-Kleiss U "Cefamandole: a competitive inhibitor of aldehyde dehydrogenase." Infection 13 (1985): 91
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