Chloral Hydrate Syrup and Renal/liver disease
Result of checking the interaction of drug Chloral Hydrate Syrup and disease Renal/liver disease for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:The use of chloral hydrate is contraindicated in patients with marked renal and/or hepatic impairment due to the potential for significant drug and metabolite accumulation. Chloral hydrate is metabolized by the liver and erythrocytes to the pharmacologically active compound, trichloroethanol (TCE), which has a plasma half-life of 8 to 12 hours. TCE is then metabolized further by both the liver and kidney to inactive substances that are slowly excreted in the urine. High plasma levels of chloral hydrate and TCE may produce respiratory depression and adverse cardiovascular effects such as peripheral vasodilation, hypotension, arrhythmias, and myocardial depression.
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- Garrett ER, Lambert HJ "Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters." J Pharm Sci 62 (1973): 550-72
- "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
Generic Name: chloral hydrate
Brand Name: Somnote
Synonyms: Chloral Hydrate Capsules