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Cholecalciferol Sublingual Spray and Hepatobiliary dysfunction

Result of checking the interaction of drug Cholecalciferol Sublingual Spray and disease Hepatobiliary dysfunction for safety when used together.

Check result:

Cholecalciferol Sublingual Spray <> Hepatobiliary dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Vitamin D analogs are fat soluble and oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin D analogs. Metabolites of vitamin D analogs are primarily excreted in bile and feces. Ergocalciferol, cholecalciferol, and dihydrotachysterol undergo hepatic hydroxylation during metabolic activation. Hepatic impairment can alter the metabolic and therapeutic activity of certain vitamin D analogs. Alternative vitamin D analogs such as calcifediol (requires renal activation) and calcitriol (active form) may be considered in patients with compromised hepatic function.

References:

"Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
"Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
"Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.

Cholecalciferol Sublingual Spray

Generic Name: cholecalciferol

Brand Name: Aqueous Vitamin D, Bio-D-Mulsion, Bio-D-Mulsion Forte, BProtected Pedia D-Vite, D-Vi-Sol, Dialyvite Vitamin D 5000, Dialyvite Vitamin D3 Max, Pronutrients Vitamin D3, Opurity Vitamin D, VitaJoy Daily D Gummies, D3 Dots, VitaMelts Vitamin D, Replesta

Synonyms: Vitamin D, Cholecalciferol

What is Cholecalciferol Sublingual Spray?