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Codeine, phenylephrine, and promethazine and Antidopaminergic effects 2

Result of checking the interaction of drug Codeine, phenylephrine, and promethazine and disease Antidopaminergic effects 2 for safety when used together.

Check result:

Codeine, phenylephrine, and promethazine <> Antidopaminergic effects 2

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Promethazine has weak central antidopaminergic activity. While its use is rarely associated with adverse effects secondary to dopaminergic blockade, large doses have produced extrapyramidal reactions. During chronic administration and/or high-dose therapy, the usual contraindications, warnings and precautions applicable to phenothiazines should be observed with promethazine.

References:

Nicholson AN "Central effects of H1 and H2 antihistamines." Aviat Space Environ Med 56 (1985): 293-8
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Schwinghammer TL, Kroboth FJ, Juhl RP "Extrapyramidal reaction secondary to oral promethazine." Clin Pharm 3 (1984): 83-5

Codeine, phenylephrine, and promethazine

Generic Name: codeine / phenylephrine / promethazine

Brand Name: Promethazine VC with Codeine, Phenergan VC with Codeine, M-Phen

Synonyms: Promethazine, Phenylephrine, and Codeine

What is Codeine, phenylephrine, and promethazine?