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Codeine Phosphate-Promethazine HCl and Antidopaminergic effects 1

Result of checking the interaction of drug Codeine Phosphate-Promethazine HCl and disease Antidopaminergic effects 1 for safety when used together.

Check result:

Codeine Phosphate-Promethazine HCl <> Antidopaminergic effects 1

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Promethazine has weak central antidopaminergic activity. While its use is rarely associated with adverse effects secondary to dopaminergic blockade, large doses have produced extrapyramidal reactions. During chronic administration and/or high-dose therapy, the usual contraindications, warnings and precautions applicable to phenothiazines should be observed with promethazine.

References:

Nicholson AN "Central effects of H1 and H2 antihistamines." Aviat Space Environ Med 56 (1985): 293-8
Schwinghammer TL, Kroboth FJ, Juhl RP "Extrapyramidal reaction secondary to oral promethazine." Clin Pharm 3 (1984): 83-5
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Codeine Phosphate-Promethazine HCl

Generic Name: codeine / promethazine

Brand Name: Codeine Phosphate-Promethazine HCl, Promethazine with Codeine, Phenergan with Codeine, Promethazine HCl and Codeine Phosphate, Promethazine HCl with Codeine

Synonyms: Codeine and promethazine, Promethazine and Codeine

What is Codeine Phosphate-Promethazine HCl?