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Crizotinib and Renal impairment

Result of checking the interaction of drug Crizotinib and disease Renal impairment for safety when used together.

Check result:

Crizotinib <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Based on a population pharmacokinetic analysis of crizotinib no starting dose adjustment is needed for patients with mild or moderate renal impairment. Care should be exercised when using this agent in patients with severe renal impairment as the exposure to crizotinib is increased in these patients. It is recommended to administer crizotinib at a dose of 250 mg taken orally once daily in patients with severe renal impairment not requiring dialysis.

Crizotinib

Generic Name: crizotinib

Brand Name: Xalkori

Synonyms: n.a.

What is Crizotinib?