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Cyclophosphamide Injection and Hepatic dysfunction

Generic Name: cyclophosphamide
Dosage Forms: n.a.
Other Brand Names: Cytoxan , Neosar , Cytoxan Lyophilized

Result of checking the interaction of drug Cyclophosphamide Injection and disease Hepatic dysfunction for safety when used together.

Check result:

Cyclophosphamide Injection <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cyclophosphamide is metabolized by the liver to a biologically active form. Metabolic activation and therapeutic activity may be altered in patients with hepatic impairment. Additionally, Veno-occlusive liver disease (VOD) sometimes with fatal outcome has been reported in patients receiving cyclophosphamide- containing regimens. VOD has also been reported to develop gradually in patients receiving long-term low-dose immunosuppressive doses of cyclophosphamide. Preexisting disturbances of hepatic function seems to also be a risk factor. Therapy with cyclophosphamide should be administered cautiously in patients with compromised hepatic function.

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