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Cycloserine and Renal dysfunction

Generic Name: cycloserine
Dosage Forms: n.a.
Other Brand Names: Seromycin

Result of checking the interaction of drug Cycloserine and disease Renal dysfunction for safety when used together.

Check result:

Cycloserine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of cycloserine is contraindicated in patients with severe renal impairment. Cycloserine is associated with a high incidence of neurotoxicities, which correlates with blood levels exceeding 30 mcg/mL. Since cycloserine is primarily eliminated by the kidney, patients with renal impairment may be more likely to experience toxicity due to inadequate drug clearance. Patients with reduced renal function should be monitored closely during therapy with cycloserine. Blood levels should be drawn weekly, and dosage adjusted accordingly.

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