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Dactinomycin and Infections

Generic Name: dactinomycin
Dosage Forms: n.a.
Other Brand Names: Cosmegen

Result of checking the interaction of drug Dactinomycin and disease Infections for safety when used together.

Check result:

Dactinomycin <> Infections

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of dactinomycin is contraindicated in patients with known or suspected varicella-zoster or herpes zoster infections. A severe, generalized, potentially fatal disease has been reported with dactinomycin use during or about the time of such infections. In addition, dactinomycin can induce myelosuppression, particularly when used with X-ray therapy. Therefore, dactinomycin therapy should be withheld, or given cautiously, in patients with an infection, depending on the severity. Close clinical monitoring of hematopoietic function is recommended whenever the drug is administered. If white blood cell and/or platelet counts are markedly decreased, therapy should be withheld to allow marrow recovery, which often takes up to three weeks.

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