Drug search by name

Dapsone (Systemic) and Bone marrow suppression

Result of checking the interaction of drug Dapsone (Systemic) and disease Bone marrow suppression for safety when used together.

Check result:

Dapsone (Systemic) <> Bone marrow suppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of dapsone has been associated with development of agranulocytosis, aplastic anemia, and other blood dyscrasias. Blood dyscrasias are more likely to occur in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Patients should be instructed to report any signs of infection (sore throat, fever, local infection, bleeding, or symptoms of anemia). Monitoring for hematologic abnormalities is recommended.

References:

Cockburn EM, Wood SM, Waller PC, Bleehen SS "Dapsone-induced agranulocytosis: spontaneous reporting data." Br J Dermatol 128 (1993): 702-3
Duhra P, Charles-Holmes R "Linear IgA disease with haemorrhagic pompholyx and dapsone-induced neutropenia." Br J Dermatol 125 (1991): 172-4
McConkey B "Adverse reactions to dapsone." Lancet 2 (1981): 525
Cook I, Kish M "Haematological safety of long-term malarial prophylaxis with dapsone-pyrimethamine." Med J Aust 143 (1985): 139-41
Hornsten P, Keisu M, Wiholm B "The incidence of agranulocytosis during treatment of dermatitis herpetiformis with dapsone as reported in Sweden, 1972 through 1988." Arch Dermatol 126 (1990): 919-22
Meyerson MA, Cohen PR "Dapsone-induced aplastic anemia in a woman with bullous systemic lupus erythematosus." Mayo Clin Proc 69 (1994): 1159-62
Potter M, Yates P, Slade R, Kennedy C "Agranulocytosis caused by dapsone therapy for granuloma annulare." J Am Acad Dermatol 20 (1989): 87-8
Raizman MB, Fay AM, Weiss JS "Dapsone induced neutropenia in patients treated for ocular cicatricial pemphigoid." Ophthalmology 101 (1994): 1805-7
Laing A "Unusual reaction to intramuscular sulfone in two leprosy patients in malaysia." Int J Lepr 48 (1980): 70
Woodbury GR, Jr Fried W, Ertle JO, Malkinson FD "Dapsone-associated agranulocytosis and severe anemia in a patient with leukocytoclastic vasculitis." J Am Acad Dermatol 28 (1993): 781-3
Kraus A, Jakez J, Palacios A "Dapsone induced sulfone syndrome and systemic lupus exacerbation." J Rheumatol 19 (1992): 178-9