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Agenerase and Vitamin K deficiency

Result of checking the interaction of drug Agenerase and disease Vitamin K deficiency for safety when used together.

Check result:
Agenerase <> Vitamin K deficiency
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Formulations of Agenerase (brand of amprenavir) provide high daily doses of vitamin E exceeding the Reference Daily Intake (adults 30 Intl units, pediatrics approximately 10 Intl units). The effects of long-term, high-dose vitamin E administration in humans are unclear. High levels of vitamin E may exacerbate the blood coagulation defect of vitamin K deficiency caused by anticoagulant therapy or malabsorption.

References:
  • "Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
Agenerase

Generic Name: amprenavir

Brand Name:

Synonyms: n.a.

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