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Depo-Provera Contraceptive injection and Bone mineral density

Result of checking the interaction of drug Depo-Provera Contraceptive injection and disease Bone mineral density for safety when used together.

Check result:

Depo-Provera Contraceptive injection <> Bone mineral density

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of intramuscular medroxyprogesterone for contraception has been shown to induce bone loss, particularly during the early years of therapy. With continued use, the decline in bone density subsequently approaches the normal rate of age-related loss. Therapy with parenteral medroxyprogesterone should be administered cautiously in patients with osteoporosis or chronic use of drugs that can reduce bone mass, such as anticonvulsants or corticosteroids.

References:

Cundy T, Evans M, Roberts H, Wattie D, Ames R, Reid IR "Bone density in women receiving depot medroxyprogesterone acetate for contraception [published erratum appears in BMJ 1991 Jul27;303(6796):220]." BMJ 303 (1991): 13-6
Paiva LC, PintoNeto AM, Faundes A "Bone density among long-term users of medroxyprogesterone acetate as a contraceptive." Contraception 58 (1998): 351-5
"Product Information. Depo-Provera (medroxyprogesterone)." Pharmacia and Upjohn, Kalamazoo, MI.
Nand SL, Wren BG, Gross BA, Heller GZ "Bone density effects of continuous estrone sulfate and varying doses of medroxyprogesterone acetate." Obstet Gynecol 93 (1999): 1009-13
Cundy T, Farquhar CM, Cornish J, Reid IR "Short-term effects of high dose oral medroxyprogesterone acetate on bone density in premenopausal women." J Clin Endocrinol Metab 81 (1996): 1014-7

Depo-Provera Contraceptive injection

Generic Name: medroxyprogesterone

Brand Name: Depo-Provera, Depo-Provera Contraceptive, Depo-subQ provera 104, Provera

Synonyms: Depo-Provera Contraceptive (injection), Depo-Provera Contraceptive

What is Depo-Provera Contraceptive injection?