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Disopyramide Phosphate and Renal dysfunction

Result of checking the interaction of drug Disopyramide Phosphate and disease Renal dysfunction for safety when used together.

Check result:

Disopyramide Phosphate <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Disopyramide is primarily eliminated by the kidney. Approximately 50% of disopyramide is excreted in the urine as unchanged drug. The serum concentration of disopyramide is increased and the elimination half-life is prolonged in patients with renal impairment. Patients with renal impairment may be at increased risk of disopyramide-associated toxicity such as hypotension, conduction disturbances, or worsening of congestive heart failure. Therapy with disopyramide should be administered cautiously and dosage and/or frequency of administration modified in patients with compromised renal function. Clinical monitoring of cardiac function (ECG) and renal function is recommended.

References:

Burk M, Peters U "Disopyramide kinetics in renal impairment: determinants of interindividual variability." Clin Pharmacol Ther 34 (1983): 331-40
"Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
Cunningham JL, Shen DD, Shudo I, Azarnoff DL "The effects of urine pH and plasma protein binding on the renal clearance of disopyramide." Clin Pharmacokinet 2 (1977): 373-83
Whiting B, Elliott HL "Disopyramide in renal impairment ." Lancet 2 (1977): 1363
Horn JR, Hughes ML "Disopyramide dialysability ." Lancet 2 (1978): 214
Inagaki Y, Amano I, Otsu T "Accumulation of a disopyramide metabolite in renal failure." ASAIO J 39 (1993): m609-13
Johnston A, Henry JA, Warrington SJ, Hamer NA "Pharmacokinetics of oral disopyramide phosphate in patients with renal impairment." Br J Clin Pharmacol 10 (1980): 245-8

Disopyramide Phosphate

Generic Name: disopyramide

Brand Name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Phosphate?