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Albendazole Tablets and Hepatobiliary dysfunction

Result of checking the interaction of drug Albendazole Tablets and disease Hepatobiliary dysfunction for safety when used together.

Check result:

Albendazole Tablets <> Hepatobiliary dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Albendazole is converted to its biologically active metabolite and further metabolized to an inactive form by the liver. Biliary excretion of albendazole is the primary route of elimination and biliary obstruction results in increased albendazole serum concentration and AUC. Metabolism and therapeutic activity may be altered in patients with hepatic impairment. Elevated liver transaminase levels have been reported in 16% of patients receiving albendazole. Therapy with albendazole should be administered cautiously in patients with compromised hepatic function. Clinical monitoring of hepatic function is recommended prior to initiation of each cycle of albendazole and at least every two weeks during therapy. Patients with elevated liver enzyme test results are at increased risk for hepatotoxicity and bone marrow suppression. Discontinue therapy if liver enzymes are significantly increased or if a clinically significant decrease in blood cell counts occur.

References:

Marriner SE, Morris DL, Dickson B, Bogan JA "Pharmacokinetics of albendazole in man." Eur J Clin Pharmacol 30 (1986): 705-8
"Product Information. Albenza (albendazole)." SmithKline Beecham, Philadelphia, PA.
Choudhuri G, Prasad RN "Jaundice due to albendazole." Indian J Gastroenterol 7 (1988): 245-6

Albendazole Tablets

Generic Name: albendazole

Brand Name: Albenza

Synonyms: Albendazole

What is Albendazole Tablets?