Drug search by name

Epinephrine Ophthalmic and Narrow angles

Result of checking the interaction of drug Epinephrine Ophthalmic and disease Narrow angles for safety when used together.

Check result:

Epinephrine Ophthalmic <> Narrow angles

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of ophthalmic preparations of epinephrine, including dipivefrin (a prodrug of epinephrine), is contraindicated in patients with narrow-angle glaucoma or anatomically narrow angles. These agents stimulate both alpha-1 and alpha-2 adrenergic receptors, thus topical administration can induce transient mydriasis, either with or without the use of concomitant miotic agents. In patients with narrow angles, any degree of pupillary dilation can provoke an acute attack of angle-closure glaucoma. In contrast, sympathomimetic agents with relative alpha-2 adrenergic selectivity such as apraclonidine and brimonidine produce little to no mydriasis at normally recommended dosages.

References:

"Product Information. Epifrin Sterile Ophthalmic Solution (epinephrine)." Allergan Inc, Irvine, CA.
Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
"Product Information. Propine (dipivefrin)." Allergan Inc, Irvine, CA.

Epinephrine Ophthalmic

Generic Name: epinephrine ophthalmic

Brand Name:

Synonyms: Epinephrine (Ophthalmic)

What is Epinephrine Ophthalmic?