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Firdapse and Renal dysfunction

Result of checking the interaction of drug Firdapse and disease Renal dysfunction for safety when used together.

Check result:

Firdapse <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Renal clearance is an elimination pathway for amifampridine and the inactive metabolite, 3-N-acetyl amifampridine, and exposure of amifampridine is higher in subjects with renal impairment. Patients with renal impairment should be initiated at the lowest recommended starting dosage (15 mg/day), and patients should be closely monitored for adverse reactions. Consider dosage modification or discontinuation in patients with renal impairment as clinically appropriate. Caution is recommended as the safety, efficacy, and pharmacokinetics of amifampridine have not been studied in patients with end-stage renal disease. No dosage recommendation can be made for patients with end-stage renal disease.

Firdapse

Generic Name: amifampridine

Brand Name: Firdapse, Ruzurgi

Synonyms: n.a.

What is Firdapse?