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Ganite and Renal dysfunction

Generic Name: gallium nitrate
Dosage Forms: on, solution, concentrate
Other Brand Names: Ganite

Result of checking the interaction of drug Ganite and disease Renal dysfunction for safety when used together.

Check result:

Ganite <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of gallium nitrate is contraindicated in patients with severe renal impairment (serum creatinine > 2.5 mg/dL). Elevations in serum creatinine and/or BUN have occurred in approximately 12% of patients treated for hypercalcemia of malignancy. Rare cases of acute renal failure have also been reported, although a causal relationship to the drug was not established. In patients with less severe renal impairment, therapy with gallium nitrate should be administered cautiously, since further depression of renal function may occur. Renal status should be closely monitored, and care taken to ensure adequate hydration and urinary output (2 L/day is recommended) both before and during treatment. Therapy should be discontinued if serum creatinine exceeds 2.5 mg/dL.

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