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Gemcitabine and Hepatic dysfunction

Result of checking the interaction of drug Gemcitabine and disease Hepatic dysfunction for safety when used together.

Check result:

Gemcitabine <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Drug induced liver injury, including liver failure and death, has been reported in patients receiving gemcitabine for injection alone or in combination with other hepatotoxic drugs. Administration of gemcitabine in patients with concurrent liver metastases or preexisting medical history of hepatitis, alcoholism, or liver cirrhosis can lead to exacerbation of any underlying hepatic insufficiency. Hepatic function should be assessed prior to initiation of therapy and during treatment. The manufacturers state that no clinical studies have been conducted with gemcitabine in patients with decreased hepatic function.

References:

"Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company, Indianapolis, IN.
Guchelaar HJ, Richel DJ, Vanknapen A "Clinical, toxicological and pharmacological aspects of gemcitabine." Cancer Treat Rev 22 (1996): 15-31

Gemcitabine

Generic Name: gemcitabine

Brand Name: Gemzar, Infugem

Synonyms: n.a.

What is Gemcitabine?