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Gemfibrozil and Liver disease

Result of checking the interaction of drug Gemfibrozil and disease Liver disease for safety when used together.

Check result:

Gemfibrozil <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of gemfibrozil is considered by the manufacturer to be contraindicated in patients with hepatic impairment. Gemfibrozil is primarily metabolized by the liver. Decreased drug metabolism may lead to accumulation and increased risk of toxicity, including biochemical abnormalities of liver function and musculoskeletal adverse effects. Therapy with gemfibrozil should be administered cautiously in patients with active liver disease. Liver function tests, including serum transaminase levels, should be performed periodically. Therapy should be withdrawn if persistent abnormalities occur and are thought to be related to the drug.

References:

Miller DB, Spence JD "Clinical pharmacokinetics of fibric acid derivatives (fibrates)." Clin Pharmacokinet 34 (1998): 155-62
Knauf H, Kolle EU, Mutschler E "Gemfibrozil absorption and elimination in kidney and liver disease." Klin Wochenschr 68 (1990): 692-8
"Product Information. Lopid (gemfibrozil)." Parke-Davis, Morris Plains, NJ.
Todd PA, Ward A "Gemfibrozil: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia." Drugs 36 (1988): 314-39
Cayen MN "Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man." Pharmacol Ther 29 (1985): 157-204

Gemfibrozil

Generic Name: gemfibrozil

Brand Name: Lopid

Synonyms: n.a.

What is Gemfibrozil?