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Horizant and Renal dysfunction
Result of checking the interaction of drug Horizant and disease Renal dysfunction for safety when used together.
Check result:
Horizant <> Renal dysfunction
Relevance: 23.07.2019
Reviewer: Shkutko P.M., M.D., in
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Gabapentin is primarily eliminated unchanged by the kidney. Therapy with gabapentin should be administered cautiously in patients with impaired renal function. Dosage adjustments and titration should be made in accordance with product package labeling and individual patient response.
References:
- Vollmer KO, von Hodenberg A, Kolle EU "Pharmacokinetics and metabolism of gabapentin in rat, dog and man." Arzneimittelforschung 36 (1986): 830-9
- Mclean MJ "Clinical pharmacokinetics of gabapentin." Neurology 44 (1994): 17-22
- "Product Information. Neurontin (gabapentin)." Parke-Davis, Morris Plains, NJ.
- Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P, Bockbrader H, Tuerck D, Busch JA, Reece PA, et al "Pharmacokinetics of gabapentin in subjects with various degrees of renal function." Clin Pharmacol Ther 56 (1994): 154-9
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