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Hydroxyurea and Renal dysfunction

Generic Name: hydroxyurea
Dosage Forms: n.a.
Other Brand Names: Droxia , Hydrea , Mylocel , Siklos

Result of checking the interaction of drug Hydroxyurea and disease Renal dysfunction for safety when used together.

Check result:

Hydroxyurea <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hydroxyurea is primarily eliminated by the kidney. Approximately 80% of urea is excreted in the urine as unchanged drug or urea. Patients with marked renal impairment (CrCl < 60 mL/min or ESRD) may be at increased risk of toxicity associated with administration of hydroxyurea. Therapy with hydroxyurea should be administered cautiously to patients with compromised renal function.

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